- Enzyme Inhibition -
Enzyme inhibition: enzyme inhibitors are substances that directly or indirectly interfere with the function of the active site of an enzyme, reducing its activity.
Competitive inhibitors: inhibitors have a molecular shape which would be similar to the substrate, which allows them to occupy the active site instead of the substrate, competing with the substrate molecule.
If the substrate concentration is increased, the effect of the inhibitor rescued.
The inhibitors is not permanently bound to the active site thus when it leaves, another molecule can take it place.
The concentration of the inhibitor determines how long it will take for all substrate molecules to occupy the active site.
- Non competitive inhibitors -
They alter the shape of the enzyme and active site which means that substrate molecules can no longer occupy it and so the enzyme cannot function. Because the inhibitor and the substrate are not competing for the same site, an increase in substrate concentration does not decrease the effect of the inhibitor.
Modulators, moderators, or modifiers refer to compounds that influence the rates of enzyme-catalyzed reactions. The effect of enzyme inhibitors is usually to reduce the rate, while the enzyme activators can increase the rate of enzyme reaction. enzyme inhibition
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